Wednesday, February 5, 2025

 



Willow to Heart

Raffaele Piria, an Italian chemist, was the first to extract salicylic acid from willow bark in 1838. He named it salicylic acid after the Latin word salix, which means "willow



Raffaele Piria (Scilla 20 August 1814 – Turin 18 July 1865) was an Italian chemist from Scilla, who lived in Palmi. He converted the substance Salicin into a sugar and a second component, which on oxidation becomes salicylic acid, a major component of the analgesic drug Aspirin (acetylsalicylic acid).[1] Other reactions discovered by Piria were the conversion of aspartic acid to malic acid by action of nitrogen dioxide,[2] and the reaction of aromatic nitro compounds with sulfite towards aminosulfonic acids.[3]


  • Henri LerouxA French pharmacist who isolated salicin from willow bark in 1826 
  • Johann Andreas BuchnerA German pharmacologist who purified salicin in 1828 and named it salicin 
  • Felix HoffmannA researcher at Bayer who chemically modified salicylic acid to create aspirin 








2-Hydroxybenzoic acid  (or)

                                    Salicylic acid










Indian Willow 

(Salix tetrasperma)

  • Hindi: बेद लैला (Bed Laila)
  • Assamese: ভেহ (Bhe)
  • Kannada: ಬೈಚೆ ಮರ (Baiche Mara), ನೀರುವಂಜಿ (Neeruvanji)
  • Konkani: वाळुंज (Walunj)
  • Bengali: পানী জমা (Pani Joma)
  • Kashmiri: वीर् (Vir)
  • Tamil: வஞ்சி
     


Natural Occurence

Salicylic acid is a naturally occurring compound, which can be isolated from the bark of the willow tree. It can also be synthetically produced, either by biosynthesis of the amino acid phenylalanine, or from phenol. Naturally, salicylic acid and its derivatives are also found in fruits, particularly berries, and vegetables.















A type of addition reaction called the Kolbe reaction is named after Hermann Kolbe and Rudolf Schmitt. It is also known as the Kolbe-Schmitt Reaction or Carboxylation reaction. The Kolbe-Schmitt reaction involves the utilization of carbon dioxide gas, a base, and acid to transform phenol into hydroxy-benzoic acid.
  




Sources:
https://en.wikipedia.org/wiki/Raffaele_Piria
https://efloraofindia.com/efi/salix-tetrasperma/
https://en.wikipedia.org/wiki/Salicylic_acid
https://www.slideshare.net/slideshow/introduction-and-preparation-of-salicylic-acid/47690414



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